Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl) alkyl] derivatives of quinazoline-2, 4 (1H, 3H)-diones, quinazolin-4 (3H)-ones …

WB Wright Jr, AS Tomcufcik, PS Chan…

Index: Wright Jr.; Tomcufcik; Chan; Marisco; Press Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2277 - 2283

Full Text: HTML

Citation Number: 29

Abstract

N-[(1H-imidazol-l-yl) alkyl]-1H-isoindole-1, 3 (2H)-diones which were the subject of a previous report from our laboratories. These compounds were evaluated as thromboxane (TX) synthetase inhibitors and as antihypertensive agents. While each series of compounds had activity both as TX synthetase inhibitors and as antihypertensives, the best compounds were N-[(1H-imidazol-l-yl) alkyl] quinazoline-2, 4 (lH, 3~-diones (V). In general these ...