Organic letters

One-Step Synthesis of α-Chloro Acetophenones from Acid Chlorides and Aryl Precursors

J Rosen, D Steinhuebel, M Palucki, I Davies

Index: Rosen, Jonathan; Steinhuebel, Dietrich; Palucki, Michael; Davies, Ian Organic Letters, 2007 , vol. 9, # 4 p. 667 - 669

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Citation Number: 8

Abstract

A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry.