A general synthesis of optically active γ-butyrolactone autoregulators is developed by a two- step sequence to assemble 2, 3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of alkyl- substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.
[Jacobine, Alexander M.; Puchlopek, Angela L.A.; Zercher, Charles K.; Briggs, Jon B.; Jasinski, Jerry P.; Butcher, Raymond J. Tetrahedron, 2012 , vol. 68, # 38 p. 7799 - 7805]
