3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3, 5-Disubstituted-[1, 1'-biphenyl]-2-yl)-3, 5-dihydroxy-6-heptenoic acids and their lactone …

GE Stokker, AW Alberts, PS Anderson…

Index: Stokker, G. E.; Alberts, A. W.; Anderson, P. S.; Cragoe, E. J.; Deana, A. A.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 170 - 181

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Citation Number: 63

Abstract

GE Stokker,*t AW Alberts,$ P. S. Anderson,? EJ Cragoe, Jr.,t A. A. Deana,t J. L. Gilfillan,t J. Hirshfield,* W. J. Holtz,? W. F. Hoffman,? J. W. Huff,t TJ Lee,t FC Novello,t J. D. Prugh,t C. S. Rooney,' RL Smith,+ and A. K. Willard+,! ... Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486, and Rahway, New Jersey 07065. Received May 2, 1985 ... The syntheses of a series of 7-(3,5-disubstituted [ l,l'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic