Lipase catalysed synthesis of optically enriched α-haloamides

A Azim, SK Sharma, CE Olsen, VS Parmar

Index: Azim, Abul; Sharma, Sunil K.; Olsen, Carl E.; Parmar, Virinder S. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1345 - 1348

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Citation Number: 21

Abstract

An efficient lipase catalysed synthesis of optically enriched α-halogenated amides with concomitant optical enrichment of the starting α-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.