Study on the reactivity of the alkyne component in ruthenium-catalyzed [2+ 2] cycloadditions between an alkene and an alkyne

RW Jordan, K Villeneuve, W Tam

Index: Jordan, Robert W.; Villeneuve, Karine; Tam, William Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5830 - 5833

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Citation Number: 36

Abstract

The ruthenium-catalyzed [2+ 2] cycloadditions of norbornadiene with a variety of alkynes have been investigated. Electronic effect of the alkyne component has shown to play an important role on the rate of the cycloaddition, and the reactivity of the alkyne component increases dramatically as the alkyne becomes more electron deficient. Increase in the steric bulk of the alkyne component decreases the reactivity of the alkyne component. It was ...