Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

…, CR Oliveira, MLM Serralheiro, MA Santos

Index: Sebestik, Jaroslav; Marques, Sergio M.; Fale, Pedro L.; Santos, Susana; Arduino, Daniela M.; Cardoso, Sandra M.; Oliveira, Catarina R.; Serralheiro, M. Luisa M.; Santos, M. Amelia Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 4 p. 485 - 497

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Citation Number: 18

Abstract

Because of the complex cascade of molecular events that can occur in the brain of an Alzheimer's disease (AD) patient, the therapy of this neurodegenerative disease seems more likely to be achieved by multifunctional drugs. Herein, a new series of dual-targeting ligands have been developed and in vitro bioevaluated. Their architecture is based on conjugating the acetylcholinesterase inhibition and anti-oxidant properties in one ...