European journal of organic chemistry

Iron??Catalyzed Cross??Coupling between 1??Bromoalkynes and Grignard??Derived Organocuprate Reagents

D Castagnolo, M Botta

Index: Castagnolo, Daniele; Botta, Maurizio European Journal of Organic Chemistry, 2010 , # 24 p. 4732 - 4732

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Citation Number: 17

Abstract

Abstract An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of ...