e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis
F Jabeen, PV Oliferenko, AA Oliferenko…
Index: Jabeen, Farukh; Oliferenko, Polina V.; Oliferenko, Alexander A.; Pillai, Girinath G.; Ansari, Farzana Latif; Hall, C. Dennis; Katritzky, Alan R. European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 228 - 242
Abstract A striking dual inhibition of enzymes α-glucosidase and butyrylcholinesterase by small drug-like molecules, including 1, 4-disubstituted-1, 2, 3-triazoles, chalcones, and benzothiazepines, was rationalized with the help of Molecular Field Topology Analysis, a 3D QSAR technique similar to CoMFA. A common pharmacophore supported the concept of a link existing between type-2 diabetes mellitus and Alzheimer's disease. These findings ...
[Chate, Asha V.; Joshi, Ratnadeep S.; Mandhane, Priyanka G.; Gill, Charansingh H. Journal of the Korean Chemical Society, 2011 , vol. 55, # 5 p. 776 - 780]