Tetrahedron

One-step reaction leading to new pyrazolo [1, 5-a] pyrimidines by condensation of 2-pyrone with 5 (3)-amino-3 (5)-arylpyrazoles

I Bassoude, S Berteina-Raboin, JM Leger, C Jarry…

Index: Bassoude, Ibtissam; Berteina-Raboin, Sabine; Leger, Jean-Michel; Jarry, Christian; Essassi, El Mokhtar; Guillaumet, Gerald Tetrahedron, 2011 , vol. 67, # 12 p. 2279 - 2286

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Citation Number: 14

Abstract

Condensation of 5 (3)-amino-3 (5)-arylpyrazoles with 4-hydroxy-6-methylpyran-2-one leads to 5, 7-dimethyl-2-arylpyrazolo [1, 5-a] pyrimidines, 5-alkoxycarbonylmethyl-7-methyl-2- arylpyrazolo [1, 5-a] pyrimidines and their isomeric 7-alkoxycarbonylmethyl-5-methyl-2- arylpyrazolo [1, 5-a] pyrimidines. These compounds result from competitive reactions and from different cyclization pathways. Structure and mechanism of formation of these new ...