Molecules

Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners

B Sadek, KMS Fahelelbom

Index: Sadek, Bassem; Fahelelbom, Khairi Mustafa Salem Molecules, 2011 , vol. 16, # 6 p. 4339 - 4347

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Citation Number: 14

Abstract

Abstract A series of 1, 3-oxazole, 1, 3-thiazole, isomeric 1, 2, 4-oxadiazole, 1, 3, 4- oxadiazole, and 1, 2, 3, 4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl substituent. The structures of the synthesized compounds were confirmed by MS, 1 H-NMR, and elemental analysis. In vitro antimicrobial activity for all the newly synthesized compounds at concentrations of 200-25 ...