Journal of the American Chemical Society

Polyphosphoric Acid as a Reagent in Organic Chemistry. VII. Acylation1

HR Snyder, CT Elston

Index: Snyder; Elston Journal of the American Chemical Society, 1955 , vol. 77, p. 364

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Citation Number: 28

Abstract

The synthesis of ketones by intermolecular acylation with carboxylic acids in the presence of polyphosphoric acid is examined further. Thiophene and phenol are acetylated at 75', in good yields, but less reactive compounds like benzene and toluene react with aliphatic acids only under conditions vigorous enough to cause self-condensation of the resulting ketones. Fully aromatic ketones are more stable to polyphosphoric acid; toluene and ...