The Journal of Organic Chemistry

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl) amines. Preparation of Highly Useful Fluoroalkylated …

T Fuchigami, S Ichikawa

Index: Fuchigami, Toshio; Ichikawa,, Shinji Journal of Organic Chemistry, 1994 , vol. 59, # 3 p. 607 - 615

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Citation Number: 59

Abstract

Anodic methoxylation of various types of N-(fluoroethyl) amines, ArRNCH2Rf (Rf= CF3, CHF2, CHzF, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position a to the fluoromethyl (Rf) group, depending on the Rf and R groups. The effect of the Rf group on the promotion of the anodic a-methoxylation decreased in the order CF3, CHF2, and CH2F. This remarkable ...