Synthetic and novel biocatalytic resolution studies on (±)-5/6/7-acetoxy-4-aryl-3, 4-dihydrocoumarins

…, CE Olsen, AL Cholli, LA Samuelson, J Kumar…

Index: Singh, Ishwar; Prasad, Ashok K.; Sharma, Ajendra K.; Saxena, Rajendra K.; Olsen, Carl E.; Cholli, Ashok L.; Samuelson, Lynne A.; Kumar, Jayant; Watterson, Arthur C.; Parmar, Virinder S. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 529 - 538

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Citation Number: 21

Abstract

Eleven (±)-5/6/7-acetoxy-4-aryl-3, 4-dihydrocoumarins have been synthesised in two steps starting from the coupling of cinnamic acid/substituted cinnamic acid with appropriate phenols, followed by acetylation in 50–83% overall yields. All hydroxy-and acetoxycoumarins were unambiguously identified on the basis of their spectral data. Candida antarctica lipase-catalysed deacetylation of these racemic ...