QSAR study for a novel series of ortho disubstituted phenoxy analogues of α 1-adrenoceptor antagonist WB4101

M Pallavicini, L Fumagalli, M Gobbi, C Bolchi…

Index: Pallavicini; Fumagalli; Gobbi; Bolchi; Colleoni; Moroni; Pedretti; Rusconi; Vistoli; Valoti European Journal of Medicinal Chemistry, 2006 , vol. 41, # 9 p. 1025 - 1040

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Citation Number: 22

Abstract

On the basis of the affinities at the α1a-, α1b-and α1d-adrenoceptors and the 5-HT1A receptor of a previous series of sixteen 2-[(2-phenoxyethyl) aminomethyl]-1, 4- benzodioxanes ortho monosubstituted at the phenoxy moiety, a number of ortho disubstituted analogues were designed, synthesized in both the enantiomeric forms and tested in binding assays on the same receptors. The affinity values of the new compounds ...