Organic letters

Heteroatom-Guided, Palladium-Catalyzed Regioselective C–H Functionalization in the Synthesis of 3-Arylquinolines

VK Tiwari, GG Pawar, R Das, A Adhikary…

Index: Tiwari, Virendra Kumar; Pawar, Govind Goroba; Das, Riki; Adhikary, Amit; Kapur, Manmohan Organic Letters, 2013 , vol. 15, # 13 p. 3310 - 3313

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Citation Number: 13

Abstract

A new approach for the regioselective functionalization of the C-3-position of quinolines is described. The method utilizes heteroatom guided regioselective C-3 palladation followed by arylation via transmetalation with aryl boronic acids to yield 3-aryl-N-acyl-1, 2- dihydroquinolines. In a one-pot sequence, N-deacylation followed by aromatization leads to important 3-arylquinolines in good yields.