Design and Synthesis of a Class of Twin??Chain Amphiphiles for Self??Assembled Monolayer??Based Electrochemical Biosensor Applications

…, SJP Cañete, RY Lai, PH Dussault

Index: Fisher, Thomas J.; Canete, Socrates Jose P.; Lai, Rebecca Y.; Dussault, Patrick H. European Journal of Organic Chemistry, 2013 , # 16 p. 3263 - 3270

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Abstract

Abstract A new class of twin-chain hydroxyalkylthiols (mercaptoalkanols) is described that features a nearly constant cross section and the potential for modification at one or both termini. These compounds are regioselectively available through Pd-mediated couplings of benzene diiododitriflate, and their syntheses include an example of a previously unreported coupling reaction to generate an ortho-substituted arene bis (acetic acid). In an ...