Thiadiazole??based Thioglycosides as Sodium??glucose Co??transporter 2 (SGLT2) Inhibitors

Y Gao, G Zhao, W Liu, Y Wang, W Xu…

Index: Gao, Yunlong; Zhao, Guilong; Liu, Wei; Wang, Yuli; Xu, Weiren; Wang, Jianwu Chinese Journal of Chemistry, 2010 , vol. 28, # 4 p. 605 - 612

Full Text: HTML

Citation Number: 16

Abstract

Abstract A series of thiadiazole-based thioglycosides were synthesized as SGLT2 inhibitors from D-glucose, D-galactose and a variety of phenylacetic acids via a convenient protocol in 8 steps and evaluated in vivo with an oral glucose tolerance test (OGTT), and 5-benzyl-1, 3, 4-thiadiazol-2-yl 1-thio-β-D-glucopyranoside (1a) was the most efficacious to suppress the blood glucose excursion during OGTT.