New 1, 4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents

…, S Galiano, I Aldana, A Monge, S Pérez-Silanes

Index: Torres, Enrique; Moreno, Elsa; Ancizu, Saioa; Barea, Carlos; Galiano, Silvia; Aldana, Ignacio; Monge, Antonio; Perez-Silanes, Silvia Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3699 - 3703

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Citation Number: 43

Abstract

Abstract The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1, 4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium ...