BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

…, J Harnett, A Rolland, C Lanco, L Lesueur-Ginot…

Index: Lavergne, Olivier; Harnett, Jeremiah; Rolland, Alain; Lanco, Christophe; Lesueur-Ginot, Laurence; Demarquay, Daniele; Huchet, Marion; Coulomb, Helene; Bigg, Dennis C. H. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2599 - 2602

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Citation Number: 59

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines. ... All new compounds gave satisfactory analysis and ...