Synthesis

Copper-Catalyzed Aerobic Methyl/Methylene Oxygenation and C–H Formylation with a DABCO–DMSO System for the Synthesis of Carbonyl Indoles and Pyrroles

YF Wang, FL Zhang, S Chiba

Index: Wang, Yi-Feng; Zhang, Feng-Lian; Chiba, Shunsuke Synthesis, 2012 , vol. 44, # 10 p. 1526 - 1534

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Citation Number: 15

Abstract

Abstract Copper-catalyzed aerobic methyl/methylene oxygenation of substituted indoles and pyrroles was developed using 1, 4-diazabicyclo [2.2. 2] octane (DABCO) as an additive in dimethyl sulfoxide (DMSO). Similar aerobic catalytic conditions could also be utilized for direct C–H formylation of C (3) on indoles and C (2) on pyrroles.

~28%

~78%

~52%

~97%

~83%

~35%

~33%

~46%

~61%

~33%

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