Tetrahedron Letters

The oxidation of aldehydes to acids with calcium hypochlorite [Ca (OCl) 2]

SO Nwaukwa, PM Keehn

Index: Nwaukwa, Stephen O.; Keehn, Philip M. Tetrahedron Letters, 1982 , vol. 23, # 31 p. 3131 - 3134

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Citation Number: 52

Abstract

Abstract Calcium hypochlorite is an efficient reagent for the oxidation of aldehydes to the corresponding acids. Reactions are carried out at ambient temperature in aqueous acetonitrile-acetic acid solution. Aliphatic aldehydes and aromatic aldehydes with electron withdrawing groups afford good to excellent yields. Nuclear chlorination is the preferred reaction in aromatic aldehydes with electron donating groups.