Discovery of Functionally Selective 7, 8, 9, 10-Tetrahydro-7, 10-ethano-1, 2, 4-triazolo [3, 4-a] phthalazines as GABAA Receptor Agonists at the α3 Subunit

…, JR Atack, FA Bromidge, SM Cook, P Hunt…

Index: Julia, Sebastian; Martinez-Martorell, Carlos; Elguero, Jose Heterocycles, 1986 , vol. 24, # 8 p. 2233 - 2237

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Citation Number: 40

Abstract

... Volume: Page: ... The final compounds were all synthesized through the 3-substituted 6-chloro-7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines (101a ... reflux, 4 d; (iv) NH 2 NH 2 ·H 2 O, EtOH, reflux, 18 h; (v) R 1 COCl, Et 3 N, CHCl 3 , rt, 4−24 h; (vi ...