Tetrahedron

Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI

…, MR Sablone, G Bianchini, A Amore, M Fanì, P Perrone…

Index: Aramini, Andrea; Sablone, Manolo R.; Bianchini, Gianluca; Amore, Alessia; Fani, Michela; Perrone, Plinio; Dolce, Alberto; Allegretti, Marcello Tetrahedron, 2009 , vol. 65, # 10 p. 2015 - 2021

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Citation Number: 17

Abstract

A novel one-pot two-step procedure has been developed to synthesize highly substituted 2- arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic ...