Tetrahedron

Tetrahydropyrido [d] pyridazinones—promising scaffolds for drug discovery

AG Yaremenko, DM Volochnyuk, VV Shelyakin…

Index: Yaremenko, Anatoliy G.; Volochnyuk, Dmitriy M.; Shelyakin, Vyacheslav V.; Grygorenko, Oleksandr O. Tetrahedron, 2013 , vol. 69, # 33 p. 6799 - 6803

Full Text: HTML

Citation Number: 4

Abstract

An approach to the synthesis of all possible tetrahydropyrido [d] pyridazinones has been developed. The method relies on the catalytic hydrogenation of the corresponding aromatic counterparts, which were obtained by cyclization of the relevant dibromomethyl-substituted pyridinecarboxylates with hydrazine. The synthetic schemes include 4–5 steps starting from commercially available materials. The tetrahydropyrido [d] pyridazinone scaffolds are ...