Tetrahedron Letters

Reactivity of mixed organozinc and mixed organocopper reagents: 6. Nickel-catalyzed coupling of methylarylzincs with primary alkyl halides; an atom-economic aryl– …

ÖÖ Pekel, E Erdik

Index: Pekel, Oezgen Oemuer; Erdik, Ender Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7087 - 7090

Full Text: HTML

Citation Number: 8

Abstract

A nickel-catalyzed process for the cross-coupling of mixed arylzincs and primary alkyl halides has been developed. The reaction of a methylarylzinc with a primary alkyl halide in THF in the presence of NiCl2/PPh3 takes place with selective aryl transfer at room temperature in moderate yields. This protocol provides an atom-economic alternative to aryl– primary alkyl coupling using diarylzincs.