Cobalt-catalyzed low pressure double carbonylation of aryl and secondary benzyl halides

F Francalanci, E Bencini, A Gardano, M Vincenti…

Index: Francalanci, F.; Bencini, E.; Gardano, A.; Vincenti, M.; Foa, M. Journal of Organometallic Chemistry, 1986 , vol. 301, p. C27 - C30

Full Text: HTML

Citation Number: 29

Abstract

Abstract α-Ketoacids can be easily synthesized with satisfactory yields and selectivities by carbonylation of aryl halides and secondary benzyl halides under very mild conditions. The reactions are catalyzed by Co 2 (CO) 8 in alcoholic solvents; the presence of a methyl source (dimethyl sulfate or methyl iodide) is necessary for the carbonylation of the aryl halides. Base, temperature and solvent have large effects on the course of the reaction.