Helvetica Chimica Acta

Reduction of Indolin??2??ones and Desulfurization of Indoline??2??thiones to Indoline and Indole Derivatives

T Nishio, N Okuda, C Kashima

Index: Nishio, Takehiko; Okuda, Norikazu; Kashima, Choji Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1719 - 1723

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Citation Number: 21

Abstract

Abstract Reduction of indolin-2-ones with lithium aluminium hydride (LAH) or diisobutylaluminum hydride (DIBAL) and desulfurization of indoline-2-thiones with Raney-Ni were investigated. Treatment of indoline-2-ones 1 with LAH or DIBAL yield indoles 4 and/or indolines 3 in moderate-to high yield depending on the substituents at N and C (3) of 1. Indoline-2-thiones 2 were desulfurized with Raney-Ni to give indoles 4 and/or indolines 3.