Total synthesis of swinholide A and hemiswinholide A

…, KS Yeung, RA Ward, JG Cumming…

Index: Paterson, Ian; Yeung, Kap-Sun; Ward, Richard A.; Cumming, John G.; Smith, Julian D. Journal of the American Chemical Society, 1994 , vol. 116, # 20 p. 9391 - 9392

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Citation Number: 63

Abstract

Swinholide A, a complex polyketide metabolite isolated from the marine sponge Theonella swinhoei, was first reported by Carmely and Kashman in 1985.'Using NMR methods and chemical derivatization, its gross structure was initially misassigned as a monomeric 22- membered macrolide. Subsequently, Kitagawa and co-workers elucidated the true dimeric nature of swinholideA (l), as well as determining the full stereochemistry, by mass ...