Enzymatic synthesis of cholecystokinin-octapeptide.

K SAKINA, K KAWAZURA, K MORIHARA…

Index: Sakina; Kawazura; Morihara; Yajima Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3915 - 3919

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Citation Number: 19

Abstract

Cholecystokinin-octapeptide was synthesized by enzymatic condensations of three fragments, without side-chain protection, except for Tyr. Fmoc-Asp-Tyr (SO 3 Ba1/2)-OH, prepared by the concerted action of proteases, followed by pyridinium trifluoroacetylsulfate treatment, was used as the N-terminal fragment. In the final step, the Nα-Fmoc group employed as a sole protecting group was easily removed by base treatment without ...