Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3 R)-7-Hydroxy-N-[(1 S)-1-{[(3 R, 4 R)-4-(3-hydroxyphenyl)-3, 4- …

…, JB Thomas, HA Navarro, FI Carroll

Index: Liu, Cong; Thomas, James B.; Brieaddy, Larry; Berrang, Bertold; Carroll, F. Ivy Synthesis, 2008 , # 6 p. 856 - 858

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Citation Number: 14

Abstract

In previous structure− activity relationship (SAR) studies,(3 R)-7-hydroxy-N-[(1 S)-1-{[(3 R, 4 R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl] methyl}-2-methylpropyl]-1, 2, 3, 4- tetrahydro-3-isoquinolinecarboxamide (JDTic, 3) was identified as the first potent and