Toward a better understanding on the mechanism of ortholithiation. Tuning of selectivities in the metalation of meta-anisic acid by an appropriate choice of base

TH Nguyen, NTT Chau, AS Castanet, KPP Nguyen…

Index: Organic Letters, , vol. 7, # 12 p. 2445 - 2448

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Citation Number: 33

Abstract

... Volume: Page: ... Organic Letters. ... acid (12) as a single regioisomer, it is reasonable to assume that s-BuLi/TMEDA metalates 6 randomly at the C-2, C-4, and C-6 sites and that there is no interconversion of the resulting organometallic species 7−9. Consequently ...