Synthesis and evaluation of novel 18F labeled 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives as ligands for positron emission tomography (PET) …

…, X Wang, P Yu, J Zhang, Z Li, X Zhang…

Index: Qiao, Jennifer X.; Wang, Tammy C.; Hu, Carol; Li, Jianqing; Wexler, Ruth R.; Lam, Patrick Y. S. Organic Letters, 2011 , vol. 13, # 7 p. 1804 - 1807

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Citation Number: 24

Abstract

A series of fluoro-pegylated (FPEG) 2-pyridinylbenzoxazole and 2-pyridinylbenzothiazole derivatives were synthesized and evaluated as novel β-amyloid (Aβ) imaging probes for PET. They displayed binding affinities for Aβ1–42 aggregates that varied from 2.7 to 101.6 ...