Tetrahedron Letters

One-step conversion to tertiary amines: InBr 3/Et 3 SiH-mediated reductive deoxygenation of tertiary amides

N Sakai, K Fujii, T Konakahara

Index: Sakai, Norio; Fujii, Kohji; Konakahara, Takeo Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6873 - 6875

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Citation Number: 76

Abstract

We have developed a simple and practical procedure for a direct reductive conversion from a variety of tertiary amides to the corresponding tertiary amines using an InBr3/Et3SiH reducing system. This reducing system can be applied to the reduction of a secondary amide and provides a more efficient alternative to conventional methods that use aluminum and boron hydrides.

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