Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

L Lengyel, TZ Nagy, G Sipos, R Jones, G Dormán…

Index: Lengyel, Laszlo; Nagy, Tibor Zs.; Sipos, Gellert; Jones, Richard; Dorman, Gyoergy; Uerge, Laszlo; Darvas, Ferenc Tetrahedron Letters, 2012 , vol. 53, # 7 p. 738 - 743

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Citation Number: 16

Abstract

Intramolecular thermal cyclization and benzannulation reactions of the Gould–Jacobs and Conrad–Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300–360° C and under high pressure conditions (100–160bar) with very short residence times (0.45–4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and ...