A convenient one-pot method for the synthesis of substituted quinolines via the reaction of aniline and aldehyde in the presence of a Lewis acid (AlCl 3 ) and an oxidant (H 2 O 2 ) has been developed. Hydrogen peroxide was found to promote the reaction by its function as a hydrogen hunter, hindering the formation of by-product N-alkylaniline. The effect of the oxidant on the yield and selectivity was studied. When the molar ratio of aniline, n-butyraldehyde, and H 2 O 2 ...
[Watanabe, Yoshihisa; Suzuki, Naoki; Tsuji, Yasushi; Shim, Sang Chul; Mitsudo, Take-aki Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1116 - 1120]
