Asymmetric synthesis of the enkephalinase inhibitor thiorphan

DA Evans, DJ Mathre, WL Scott

Index: Journal of Organic Chemistry, , vol. 50, # 11 p. 1830 - 1835

Full Text: HTML

Citation Number: 114

Abstract

... SOC. 1951, 73,4199. (10) For a general review of the synthesis and chemistry of 2 ... The combined organic extracts were successively washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 41.5 g of a pale-yellow solid. ... J. Org. ...

 Related Synthetic Route
N/A Structure

95798-35-9

N/A

~75%

(S)-4-Isopropyl-2-oxazolidinone Structure

17016-83-0

(S)-4-Isopropyl...

(2S)-2-<<(phenylmethyl)thio>methyl>-3-phenylpropanoic acid ester Structure

95798-36-0

(2S)-2-<<(pheny...

(S)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one Structure

95798-31-5

(S)-4-isopropyl...

~%

(S)-4-Isopropyl-2-oxazolidinone Structure

17016-83-0

(S)-4-Isopropyl...

N/A Structure

95798-32-6

N/A

~73%

(4R,5S)-4-Methyl-5-phenyl-1,3-oxazolidin-2-one Structure

77943-39-6

(4R,5S)-4-Methy...

N/A Structure

95841-15-9

N/A

N/A Structure

95841-14-8

N/A

~%

(4R,5S)-4-Methyl-5-phenyl-1,3-oxazolidin-2-one Structure

77943-39-6

(4R,5S)-4-Methy...


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