Monomethyl ether derivatives of 7, 8-dihydroxy-and 8, 9-dihydroxy-4-propyl-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [f] quinolines as possible products of metabolism …

JG Cannon, KA Walker, A Montanari…

Index: Cannon, Joseph G.; Walker, Kathleen A.; Montanari, Antonio; Long, John Paul; Flynn, Jan R. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2000 - 2006

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Citation Number: 9

Abstract

In order to facilitate identification of possible metabolites arising from in vitro action of catechol-0-methyltransferase upon 7, 8-dihydroxy-and 8, 9-dihydroxy-4-n-propyl-1, 2, 3, 4, 4a, 5, 6, l0b-octahydrobenzo~ quinolinens (1 1, 12), all four possible monomethyl ether derivatives have been synthesized. Incubation of 11 and 12 with the enzyme revealed that the 8, g-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the fi ...