Lewis Acid-Mediated Michaelis− Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates

GG Rajeshwaran, M Nandakumar, R Sureshbabu…

Index: Rajeshwaran, Ganesan Gobi; Nandakumar, Meganathan; Sureshbabu, Radhakrishnan; Mohanakrishnan, Arasambattu K Organic Letters, 2011 , vol. 13, # 6 p. 1270 - 1273

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Citation Number: 64

Abstract

A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis− Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.

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