Stability of N-glycosidic bond of (5′ S)-8, 5′-cyclo-2′-deoxyguanosine

…, M Samaraweera, M Morton, JA Gascón…

Index: Das, Rajat S.; Samaraweera, Milinda; Morton, Martha; Gascon, Jose A.; Basu, Ashis K. Chemical Research in Toxicology, 2012 , vol. 25, # 11 p. 2451 - 2461

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Citation Number: 10

Abstract

8, 5′-Cyclopurine deoxynucleosides are unique tandem lesions containing an additional covalent bond between the base and the sugar. These mutagenic and genotoxic lesions are repaired only by nucleotide excision repair. The N-glycosidic (or C1′-N9) bond of 2′- deoxyguanosine (dG) derivatives is usually susceptible to acid hydrolysis, but even after cleavage of this bond of the cyclopurine lesions, the base would remain attached to the ...