Tetrahedron Letters

Synthesis of oligomeric assemblies of a platelet-binding key disaccharide in heparin and their biological activities

S Koshida, Y Suda, M Sobel, S Kusumoto

Index: Koshida, Shuhei; Suda, Yasuo; Sobel, Michael; Kusumoto, Shoichi Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1289 - 1292

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Citation Number: 26

Abstract

Heparin, highly sulfated glycosaminoglycan, binds to platelets. A key disaccharide unit in heparin was previously found to be responsible for the binding, and the frequency of the disaccharide unit was important for the binding potency. A newly developed method ...