Alkyne–Azide Cycloadditions with Copper Powder in a High??Pressure Continuous??Flow Reactor: High??Temperature Conditions versus the Role of Additives

…, IM Mándity, L Kiss, F Fülöp

Index: Oetvoes, Sandor B.; Mandity, Istvan M.; Kiss, Lorand; Fueloep, Ferenc Chemistry - An Asian Journal, 2013 , vol. 8, # 4 p. 800 - 808

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Citation Number: 23

Abstract

Abstract A safe and efficient flow-chemistry-based procedure is presented for 1, 3-dipolar cycloaddition reactions between organic azides and acetylenes. This simple and inexpensive technique eliminates the need for costly special apparatus and utilizes Cu powder as a plausible Cu I source. To maximize the reaction rates, high-pressure/high- temperature conditions are utilized; alternatively, the harsh reaction conditions can be ...