Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

~%

~%

~92%

~58%

~80%

~83%

~%

~%

~%

~%

~94%

~%

~%

~%

~66%

~10%

~%

~%

~78%

~%

~%

~%

~%