A new method for the catalytic aldol reaction to ketones

…, Y Suto, M Kanai, M Shibasaki

Index: Oisaki, Kounosuke; Suto, Yutaka; Kanai, Motomu; Shibasaki, Masakatsu Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5644 - 5645

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Citation Number: 108

Abstract

A new method for the catalytic aldol reaction to ketones, using CuF⊙ 3PPh3⊙ 2EtOH complex as the catalyst and (EtO) 3SiF as the additive, is described. The reaction can be applied to a wide range of ketones and trimethylsilyl enolates. On the basis of mechanistic studies, a working hypothesis for the catalytic cycle is proposed, in which the dynamic ligand exchange mediated by copper silicates produces the active copper enolate. Moreover, the ...