New Bisquaternary Isoquinolinium Inhibitors of Brain Cholinesterases-Synthesis and Anticholinesterase Activity

…, M Pohanka, M Hrabinova, V Opletalova…

Index: Binder, Jiri; Paar, Martin; Jun, Daniel; Pohanka, Miroslav; Hrabinova, Martina; Opletalova, Veronika; Kuca, Kamil Letters in Drug Design and Discovery, 2010 , vol. 7, # 1 p. 1 - 4

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Citation Number: 7

Abstract

Alzheimer's disease (AD) is one of the most discussed diseases of present time. Because of the aging of our population it is high threat for future. Due to this, new drugs combating AD are still developed. In this study, twelve bisquaternary isoquinolinium derivatives differing in the linker between two heteroarenium rings were synthesized and tested for their potency to inhibit brain cholinesterases. According to the obtained in vitro results, the ...