Tetrahydroisoquinolines by Friedel-Crafts Cyclizations Promoted by Iron (III) Chloride Hexahydrate

RA Bunce, NR Cain, JG Cooper

Index: Bunce, Richard A.; Cain, Nicholas R.; Cooper, John G. Organic Preparations and Procedures International, 2012 , vol. 44, # 2 p. 131 - 145

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Citation Number: 4

Abstract

An ongoing synthetic project required access to substituted 4, 4-dimethyl-1, 2, 3, 4- tetrahydroisoquinolines as the core ring structure for a potential drug analog. We recently reported an approach to tetrahydronaphthalenes1 via Amberlyst 15 R-promoted cyclization of 5-aryl-2-methyl-2-pentanol derivatives and hoped to extend our method2 to the preparation of this heterocyclic system. Beyond our interest in these structures, the 4, 4- ...