Synthesis

An economical and convenient synthesis of vinyl sulfones

ZH Guan, W Zuo, LB Zhao, ZH Ren, YM Liang

Index: Guan, Zheng-Hui; Zuo, Wei; Zhao, Lian-Biao; Ren, Zhi-Hui; Liang, Yong-Min Synthesis, 2007 , # 10 p. 1465 - 1470

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Citation Number: 19

Abstract

We have reported the stereoselective synthesis of (Z)-β-chlorovinyl sulfones by the addition of sulfonyl chlorides to acetylenes. [8a] However, the key to the success of the reaction lies in the use of copper(I) chloride as catalyst and dimethyl sulfide as an additive. Recently, we found that the reaction of sulfinic acid sodium salts and dibromides could be carried out at 80 °C in N,N-dimethylformamide (DMF) to give the corresponding vinyl sulfones directly in good ...