Journal of the American Chemical Society

A Highly Efficient Synthesis of. beta.-Substituted Six-and Seven-Membered-Ring Enones via Carbon Alkylation of. gamma.-Methoxy Allylsulfonyl Anions

Z Jin, PL Fuchs

Index: Jin, Zhendong; Fuchs Journal of the American Chemical Society, 1994 , vol. 116, # 13 p. 5995 - 5996

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Citation Number: 15

Abstract

A previous paper from these laboratories detailed the use of y-silyloxy vinyl sulfones 2 (Scheme 1) as the focal point of a four-step synthesis of a, &disubstituted enones 4.2 A serious deficiency of this strategy has been revealed by our recent need for@-substituted enones which bear a hydrogen in the a-position (4, R1= H). 3 This limitation has now been removed for six-and seven-membered rings by implementation of an alternative onepot ...