Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

…, AD Konstantinov, BG Chittim, EM Joyce…

Index: Chen; Konstantinov; Chittim; Joyce; Bols; Bunce Environmental Science and Technology, 2001 , vol. 35, # 18 p. 3749 - 3756

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Citation Number: 177

Abstract

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding ...