Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents

RG Britton, E Horner-Glister, OA Pomenya…

Index: Britton, Robert G.; Horner-Glister, Emma; Pomenya, Odette A.; Smith, Ewan E.; Denton, Roanne; Jenkins, Paul R.; Steward, William P.; Brown, Karen; Gescher, Andreas; Sale, Stewart European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 952 - 958

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Citation Number: 22

Abstract

A library of flavonol analogues was synthesised and evaluated as potential anticancer agents against a human prostate cancer cell line, 22rν1. Compounds 3, 8 and 11 (IC50 2.6, 3.3 and 4.0 μM respectively) showed potent cancer cell growth inhibition, comparable to the lead compound 3′, 4′, 5′-trimethoxyflavonol (1)(IC50 3.1 μM) and superior to the naturally occurring flavonols quercetin (16) and fisetin (22)(both> 15 μM). Results indicate ...